Protein Details: Cation channel sperm-associated protein 2

Protein ID

ICDB_Pro_1402

Protein Name

Cation channel sperm-associated protein 2

Gene Name

CATSPER2

Organism

Homo sapiens (Human)

Length

530 amino acids

AlphaFoldDB

AF-Q96P56-F1-model_v4.pdb

Function

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization; such as sperm hyperactivation; acrosome reaction and chemotaxis towards the oocyte.

Sequence

MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGDQHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPGLMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Deafness-Infertility Syndrome and Rare Genetic Deafness

Location

Testis-specific

DOI ID

10.1073/pnas.221454998; 10.1038/nature09769; 10.1038/nature09767; 10.1126/science.aad6887

RefSeq

NP_001269238.1 [Q96P56-2]; NP_473361.1; NP_742093.1 [Q96P56-1]; XP_016877393.1